Genomic instability is a hallmark of cancer. On one hand, genomic instability of cancer cells promotes loss of tumor suppressors and activation of oncogenes. On the other hand, genomic instability renders cancer cells susceptible to radiation and chemotherapy. The laboratory focus on dissecting mechanisms that result in compromised genomic integrity and study DNA repair pathways to understand how cells fix their genome. The long-term goal of our research is developing new strategies to eliminate cancer cells with high genomic instability to provide needed insight into potential novel targeted therapies.