2025
Manjunath, M., Santiago, G., Ortega, P., Sanchez, A., Oh, S., Garcia, A., Bournique, E., Bouin A, Semler BL, Setiaputra D, and Buisson, R. Cooperative Role of PACT and ADAR1 in Preventing Aberrant PKR Activation by Self-Derived Double-Stranded RNA. Nature Communications (2025). PMID: 40185749
Ortega, P., Bournique, E., Li, Y., Sanchez, S., Santiago, G., Brooke, H., Green, A., and Buisson, R. ATR safeguards replication forks against APOBEC3B-induced toxic PARP1 trapping. Science Advances (2025).PMID: 40238882
Ortega, P., Sanchez, S., Seldin, M., Buisson, R. Oligo-seq protocol for mapping DNA motifs targeted by base editors. STAR Protocols (2025). PMID: 40215169
Bournique, E., Sanchez, A., Oh, S., Ghazarian, D., Mahieu, A., Manjunath, L., Ednacot, E., Ortega, P., Masri, S., Marazzi, I., and Buisson, R. ATM and IRAK1 orchestrate two distinct mechanisms of NF-κB activation in response to DNA damage. Nature Structural & Molecular Biology (2025). PMID: 39753776
Yoon, Y., Bournique, E., Soles, LV., Yin, H., Chu HF., Zhuang, Y., Liu, X., Liu, L., Valdez, M., Tian, L., Huang, L., Shi, X., Ding, F., Tong, L., Buisson, R, Shi, Y. RBBP6 anchors pre-mRNA 3’ end processing to nuclear speckles.
Molecular Cell (2025). PMID: 39798570
Sanchez, A. and Buisson, R. An in vitro cytidine deaminase assay to monitor APOBEC activity on DNA. Methods in Enzymology (2025). PMID: 40250954
Smith, NJ., Reddin, I., Policelli, P., Oh, S., Zainal, N., Howes, E., Jenkins, B., Tracy, I., Edmond, M., Sharpe B., Amendra, D., Zheng, K., Egawa, N., Doorbar, J., Rao, A., Mahadevan, S., Carpenter, MA., Harris, RS, Ali, S., Hanley, C., Buisson, R., King, E., Thomas, GJ., Fenton TR. Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma. EMBO Journal (2025). PMID: 39548236
Papaioannou, D., Urs, A., Buisson, R., Petri, A., Kulkarni, R., Nicolet, D., Woodward, L., Chinmayee, G., Mrózek, K., Behbehani, GK., Kauppinen, S., Eisfeld, AK., Aifantis, I., Singh, G., Dorrance, AM, Garzon, R. circPCMTD1: A Protein-Coding Circular RNA that Regulates DNA Damage Response in BCR/ABL-Positive Leukemias. BioRxiv [Preprint]
2024
Oh, S., Santiago, G., Manjunath, L., Li,J., Bouin A., Semler, BL., and Buisson, R.. A CRISPR-Cas9 Knockout Screening Identifies IRF2 as a Key Driver of OAS3/RNase L-Mediated RNA Decay During Viral Infection. Proceedings of the National Academy of Sciences (2024). PMID: 39475651
Sanchez, A., Ortega, P., Sakhtemani, R., Manjunath, L., Oh S., Bournique, E., Becker, A., Kim, K., Durfee, C., Temiz, N., Chen, XS., Harris, RS, Lawrence, MS., & Buisson, R. Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes. Nature Communications (2024) PMID: 38499542
Boulay, G., Broye, LC., Dong, R., Iyer, S., Sanalkumar, R., Xing, H-Y., Buisson, R., Rengarajan, S., Naigles, B., Duc, B., Volorio, A., Awad, ME., Renella, R., Chebib, I., Nielsen, GP., Choy, E., Cote, GM., Zou, L., Letovanec, I., Stamenkovic, I., Rivera, MN., & Riggi, N. EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in Desmoplastic Small Round Cell Tumors. Nature Communications (2024). PMID: 39198430
Jebril Fallatah MM., Demir, O., Law, F., Lauinger, L., Baronio, R., Hall, L., Bournique, E., Tyler Metzen, L., Norman, Z., Buisson, R., Amaro, RE., and Kaiser, P. Pyrimidine Triones are potential activators of p53 mutants. Biomolecules (2024).
2023
#Manjunath, M., #Oh, S., Ortega, P., Bouin, A., Bournique, E., Sanchez, A., Martense, PM., Auerbach, AA., Becker, JT., Seldin, M., Harris, RS., Semler, BL., & Buisson, R. APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection. (2023) Nature Communications. PMID: 36781883
#co-first author
Isozaki H, Sakhtemani R, Abbasi A, Nikpour N, Stanzione M, Oh S, Langenbucher A, Monroe S, Su W, Cabanos HF, Siddiqui FM, Phan N, Jalili P, Timonina D, Bilton S, Gomez-Caraballo M, Archibald HL, Nangia V, Dionne K, Riley A, Lawlor M, Banwait MK, Cobb RG, Zou L, Dyson NJ, Ott CJ, Benes C, Getz G, Chan CS, Shaw AT, Gainor JF, Lin JJ, Sequist LV, Piotrowska Z, Yeap BY, Engelman JA, Lee JJ, Maruvka YE, Buisson R, Lawrence MS, Hata AN. Therapy-induced APOBEC3A drives evolution of persistent cancer cells. (2023) Nature. PMID: 37407818
Neubert EN., DeRogatis, JM., Lewis, SA., Viramontes, KM., Ortega, P., Henriquez, M., Buisson, R., Messaoudi, I., and Tinoco, R. HMGB2 Regulates the Differentiation and Stemness of Exhausted CD8 + T Cells During Chronic Viral Infection and Cancer. Nature Communications (2023). PMID: 37704621
Wick C., Moghadasi SA, Becker JT, Fanunza E, Oh S, Bournique E, Buisson R, Harris RS. Mitochondrial double-stranded RNA triggers induction of the antiviral DNA deaminase APOBEC3A and nuclear DNA damage. (2023) Journal of Biological Chemistry. PMID: 37474103
Su, YC., Metzen, L., Vélez, LM., Bournique, E., Seldin, M., Buisson, R., Kuo, WW., Huang, CY., and Kaiser, P. miR-29a-3p confers oxaliplatin resistance to LoVo colon cancer cells through Fem1B and Gli1 regulation. American Journal of Cancer Research. (2023) PMID: 38187042
2022
Oh, S and Buisson, R. A digital PCR-based protocol to detect and quantify RNA editing events at hotspots. (2022) STAR Protocols. PMID: 35284835
2021
#Oh, S., #Bournique, E., Bowen, D., Jalili, P., Sanchez, A., Ward, I., Dananberg, A., Manjunath, L., Tran, G., Semler, B., Maciejowski, J., Seldin, M., and Buisson, R. Genotoxic stress and Viral Infection Induce Transient Expression of APOBEC3A and Pro-Inflammatory Genes Through Two Distinct Pathways. (2021) Nature Communications. PMID: 34645815. #co-first author
#Langenbucher, A., #Bowen, D., #Sakhtemani, R., Bournique, E., Wise, J., *Zou, L., *Bhagwat, A., *Buisson, R., and *Lawrence, M. An extended APOBEC3A mutation signature in cancer. (2021) Nature Communications. PMID: 33707442 #co-first author *corresponding author
Kang,Z., Alcivar, A., Fu, P., Fu, H., Redon, C., Foo, TK., Zuo, Y., Ye, C., Baxley, R., Madireddy, A., Buisson, R., Bielinsky, AK., Zou, L., Shen, Z., Aladjem, M., and Xia, B. BRCA2 interacts with MCM10 to suppress PrimPol-mediated repriming and single-stranded DNA gap formation after DNA damage. (2021)
Nature Communications. PMID: 34389714
Zhao, K., Zhang, Q., Flanagan, S., Lang, X., Jiang, L., Parsels, LA., Parsels, JD., ZouW., Lawrence, TS., Buisson, R., Green, MD., Morgan, MA. Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-dependent Manner. (2021) Molecular Cancer Research
2020
Jalili, P., Bowen, D., Langenbucher, A., Park, P., Aguirre, K., Corcoran, R., Fleischman A., Lawrence, M., Zou, L., and Buisson, R. Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots. (2020) Nature Communications. PMID: 32532990
2019
Buisson, R., Langenbucher, A., Bowen, D., Kwan, EE., Benes, CH., Zou, L., and Lawrence, MS. Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. (2019) Science. Jun 28;364(6447).
Dubois, E., Guitton-Sert, L., Béliveau, M., Parmar, K., Chagraoui, J., Vignard, J., Pauty, J., Caron, M., Coulombe, Y., Buisson, R., Jacquet, K., Gamblin, C., Gao, Y., Laprise, P., Lebel, M., Sauvageau, G., D’Andrea, A., and Masson, J-Y. A Fanci knockout mouse model reveals common and distinct functions for FANCI and FANCD2. (2019) Nucleic Acids Research. Aug 22;47(14):7532-7547.
Moquin, DM., Genois, MM., Zhang, JM., Ouyang, J., Yadav, T., Buisson, R., Yazinski, SA., Tan, J., Boukhali, M., Gagne, JP., Poirier, GG., Lan, L., Haas, W., and Zou, L. Localized protein biotinylation at DNA damage sites identifies ZPET, a repressor of homologous recombination. (2019) Genes & Development. Jan 1;33(1-2):75-89.
2018
Cheng, X., Jobin-Robitaille, O., Billon, P., Buisson, R., Niu, H., Lacoste, N., Abshiru, N., Côté, V., Thibault, P., Kron, SJ., Sung, P., Brandl, CJ., Masson, JY., and Côté, J. Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection. (2018) Proceedings of the National Academy of Sciences. Oct 2;115(40):10028-10033
Bélanger, F., Fortier, E., Dubé, M., Lemay, JF., Buisson, R., Masson, JM., Elsherbiny, A., Costantino, S., Carmona, E., Mes-Masson, AM., Wurtele, H., and Drobetsky, E. Replication Protein A Availability During DNA Replication Stress Is a Major Determinant of Cisplatin Resistance in Ovarian Cancer Cells. (2018) Cancer Research. Oct 1;78(19):5561-5573.
Kabeche, L., Nguyen, H.D., Buisson, R., and Zou, L. A Mitosis-specific and R-loop driven ATR pathway promotes faithful chromosome segregation. (2018) Science. Jan 5;359(6371):108-114. (Commented in Science 2018 Jan 5;359(6371):30-31 and Cancer Discovery 2018 Jan;8(1):11).
2017
Boulay, B., Sandoval, GJ., Riggi, N., Iyer, S., Buisson, R., Naigles, B., Awad, ME., Rengarajan, S., Volorio, A., McBride, MJ., Broye, LB., Zou, L., Stamenkovic, I., Kadoch, C and Rivera, MN. Cancer-specific retargeting of BAF complexes by a prion-like domain. (2017) Cell. Sep 21;171(1):163-178.
Buisson, R., Lawrence, MS., Benes, CH., and Zou, L. APOBEC3A and APOBEC3B Activities Render Cancer Cells Susceptible to ATR Inhibition. (2017) Cancer Research Sep 1;77(17):4567-4578.
Yazinski, SA., Comaills, V., Buisson, R., Ho, CH., Todorova, T., Nguyen, HD., Orsulic, S., Ellisen, LW., Benes, CH., Maheswaran, S., Haber, DA., and Zou, L. ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells. (2017) Genes & Development. Feb 1;31(3):318-332.
Buisson, R., Joshi, N., Ho, CK., Rodrigue, A., Foo, TK., Hardy, E., Haas, W., Xia, B., Masson, J-Y., and Zou, L. Coupling of Homologous Recombination and the Checkpoint by ATR. (2017) Molecular Cell. 19;65(2):336-346.
2016
Comaills, V,. Kabeche, L,. Morris, R,. Buisson, R,. Yu, M,. Madden, MW,. LiCausi, JA,. Boukhali, M,. Tajima, K,. Pan, S,. Aceto, N,. Sil, S,. Zheng, Y,. Sundaresan, T,. Yae, T,. Jordan, NV,. Miyamoto, DT,. Ting, DT,. Ramaswamy, S,. Haas, W,. Zou, L,. Haber, DA,. Maheswaran, S. Genomic Instability Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition. (2016) Cell Reports. Dec 6;17(10):2632-2647
Gaullier, G., Miron, S., Pisano, S., Buisson, R., Le Bihan, YV., Tellier-Lebegue, C., Messaoud, W., Roblin, P., Guimaraes, B., Thai, R., Giraud-Panis, M-J., Gilson, E., and Le Du, M-H. A higher-order entity formed by the flexible assembly of TRF2 and RAP1. (2016) Nucleic Acids Research. Feb 29;44(4):1962-76
2015
Buisson, R., Boisvert, JL., Benes, CH., and Zou, L. Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase. (2015) Molecular Cell. Sep 17;59(6):1011-24.
2014
Pauty, P., Rodrigue, A., Couturier, A., Buisson, R., and Masson, JY., Exploring the roles of PALB2 at the crossroads of DNA repair and cancer. (2014) Biochemical Journal. Aug 1;461(3):539.
Buisson, R,. Niraj, J,. Pauty, J,. Maity R, Zhao,. W, Coulombe,. Y, Sung,. P,. and Masson, JY. Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks. (2014) Cell Reports. Feb 13;6(3):553-64.
2013
Buisson, R., and Masson, J-Y. Functions of PALB2 and BRCA2 tumor suppressors in DNA double-strand break repair. (2013) Medecine/Science. 2013 Mar;29(3):301-7.
Maity, R., Pauty, J., Krietsch, J., Buisson, R., Genois, MM., and Masson, JY. GST-His purification: A Two-step Affinity Purification Protocol Yielding Full-length Purified Proteins. (2013) Journal of Visualized Experiments. Oct 29;(80).
2012
Buisson, R., and Masson J-Y. PALB2 self-interaction controls homologous recombination. (2012) Nucleic Acids Research. 40(20):10312-23.
Genois, G., Mukherjee, A., Ubeda, JM., Buisson, R., Paquet, E., Roy, G., Plourde, G., Coulombe, Y., Ouellette, M., and Masson, JY. Interactions between BRCA2 and RAD51 for promoting homologous recombination in Leishmania infantum. (2012) Nucleic Acids Research. 40(14):6570-84
Bleuyard, JY., Buisson, R., Masson, JY., and Esashi, F. ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair. (2012) EMBO reports. 13(2):135-41
2010
Buisson, R., Dion-Côté, AM., Launay, H., Coulombe, Y., Cai, H., Stasiak, AZ., Stasiak, A., Xia, B., and Masson, JY. Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination. (2010) Nature Structural & Molecular Biology. 17(10):1247-54.
2009
*Poulet, A., *Buisson, R., Faivre-Moskalenko,C., Koelblen, M., Amiard, S., Montel, F., Cuesta-Lopez, S., Bornet, O., Guerlesquin, F., Godet, T., Moukhtar, J., Argoul, F., Déclais, AC., Lilley, DM., Ip, SC, West, SC., Gilson, E. and Giraud-Panis, MJ. TRF2 promotes and remodels telomeric Holliday Junctions. (2009) EMBO Journal. 18;28(6):641-51. (*co-first authors)
Buisson Laboratory 